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The Best Deep Wrinkle Treatment: Gentle, Natural Solutions That Support Skin Health

Restore Hyper Wellness Writer
Written by:
Restore Hyper Wellness Writer
Reviewed by Restore Medical Team
Reviewed by:
Reviewed by Restore Medical Team
15 minute read
December 3, 2025
woman gets facial for deep wrinkle treatment
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It’s not just you—it’s perfectly normal for adults over 35 to be self-conscious about how deep wrinkles can impact their appearance. 

Many people don’t take action to treat them because they are wary of injectables, lasers and other clinical aesthetic procedures that can unnaturally alter skin appearance. If that sounds familiar, you’ll be pleased to know that there are effective non-invasive solutions that can work wonders. By supporting collagen production and enhancing skin elasticity and hydration, they can soften the appearance of deep wrinkles from within.

That being said, as wrinkles aren't created overnight, their treatment can't be done in a single session either. Addressing them requires a series of thoughtfully curated therapies that work together to help rejuvenate and restore your skin. Our licensed and trained Estheticians especially recommend alternating between the Marini® Retinol Plus Facial and Neveskin™ Facial for powerful results. They can also recommend other therapies that can improve skin health for more effective results. 

Ready to target signs of aging with luxurious treatments? Keep reading for our experts' recommendations.

Highlights 

  • Deep wrinkles are influenced by factors such as age, sun exposure, repeated facial movements and loss of collagen and elastin.
  • The Marini Retinol Plus Facial and Neveskin Facial work together to support collagen production, enhance skin elasticity and improve hydration. This reduces the appearance of wrinkles.
  • Additional Restore therapies like Hydrafacial, Infrared Sauna, Red Light Therapy, IV Drip Therapy and NAD+ or Niagen (NR) IM Shots can enhance skin health and complement wrinkle-focused treatments.
  • Non-invasive therapies are safer for sensitive skin and provide natural-looking results.

What Happens in Your Skin as Deep Wrinkles Develop

You must first understand why deep wrinkles appear to evaluate what therapy can best address them. 

With age, fibroblasts (the cells that make skin structure) and proteins like collagen and elastin, which provide skin strength, resilience and elasticity, begin to decline.1 Dermis, the layer of skin responsible for keeping it plump and smooth, also becomes thinner.1 Factors like sun damage, repeated facial expressions and pollution can further accelerate this process. As skin loses resilience and its natural structure, deep wrinkles form gradually, along with other signs of skin-aging such as sagging, dryness, uneven skin tone and loss of firmness.1

As these changes happen over time, one-time interventions aren’t usually enough. Regular sessions of therapies that support these underlying biological processes are necessary to sustain lasting benefits.

What is the Best Deep Wrinkle Treatment?

Deep wrinkles form as a result of many external and internal factors, so no single treatment is “best” in an absolute sense. A combination of therapies that address different skin health issues can work well.

Many people explore a range of options, including topical skincare, injectables, lasers, ultrasound and radiotherapy to address the issue. They all can be effective to varying degrees, but require consistency for results. The final choice should depend on your preferences.

For instance, laser treatments can be effective but may require a few days to a few weeks of downtime, while needle-based treatments may cause discomfort for some people. 

The results for some treatments may also appear less natural if they are not carefully administered. Consider your goals and comfort level to select the best treatment for you.
If the goal is not just to reduce the appearance of deep wrinkles but to provide your skin with consistent support for healthy aging, Restore’s science-backed therapies can help. 

The Two Best Deep Wrinkle Facial Treatments at Restore

We have various Skin Health services that act on signs of aging, hyperpigmentation and more. 

For deep wrinkles, our licensed Estheticians recommend alternate sessions of two facials that target multiple factors behind their appearance. Together, they target skin structure and skin texture for a smoother, firmer and healthier-looking complexion:

  • Marini Retinol Plus Facial: Stimulates collagen production and slows the breakdown of existing collagen, while renewing the epidermis to improve texture and lessen the appearance of wrinkles.
  • Neveskin Facial: Enhances circulation and tones the skin, reinforcing its underlying structure for firmer-looking skin. 

Why Alternating These Two Facials Works for Deep Wrinkles

Alternating the Marini Retinol Plus and Neveskin facials improves different aspects of skin health.

Retinoid, a derivative of Vitamin A and the primary ingredient in the Marini facial, is widely established as a hero anti-aging ingredient that slows collagen breakdown due to age and speeds up skin renewal.2 It reduces the effect of enzymes called Matrix Metalloproteinases (MMPs) that break down collagen, enabling skin to repair itself effectively.1,2 

Increased activity of MMPs is linked to high exposure to UV Radiation, so retinoids are a recommended treatment for photoaging as well. Aside from wrinkles and fine lines, they act wonderfully on hyperpigmentation, improving overall skin tone.2

The Neveskin Facial, on the other hand, naturally complements retinoid treatments. 

While retinoids focus on boosting cell turnover and supporting collagen preservation, they can leave the skin more sensitive as it renews.3 

Neveskin’s controlled cooling techniques may help reduce local inflammation and activate protective antioxidant and metabolic responses associated with healthy aging.4 These effects can help keep the skin calm and balanced, creating better conditions for ongoing renewal.

The Marini Retinol Plus Facial

The Marini Retinol Plus Facial is a powerhouse designed to combat various signs of aging, including fine lines, wrinkles, uneven texture and photodamage. Leveraging the transformative power of concentrated retinol, peptides and advanced skincare technologies, this facial helps to visibly rejuvenate your skin.

The Marini Retinol Plus Facial Experience

To help repair your skin while restoring hydration, this facial includes:

  • Citrus-Infused Cleanse: A refreshing cleanse removes makeup, impurities and debris to prepare the skin.
  • Double Cleanse with Papaya Enzymes: This second cleanse uses papaya enzymes to exfoliate and prime the skin for the treatment mask.
  • Enzymatic Resurfacing Mask: A papaya-based mask is massaged into the skin to gently but effectively exfoliate, even on sensitive skin types.
  • Retinol Treatment Mask: This mask features high concentrations of retinol, anti-aging peptides and soothing ingredients to target wrinkles, texture issues and blemishes.

We amplify the facial’s rejuvenating effects with:

  • Vitamin C Serum: Helps brighten and protect the skin.
  • Hydrating Complex: With peptides, antioxidants, growth factors and hyaluronic acid, this step helps repair and restore hydration.
  • Eye Gel Treatment: A patented formula targets dark circles, fine lines and puffiness.
  • Broad-Spectrum Sunscreen: A luxurious, antioxidant-rich sunscreen seals in protection and hydration.

Have sensitive skin? This facial is ideal for all skin types and provides visible improvement after just one session.

The Neveskin Facial

The Neveskin Facial harnesses the power of cold therapy to help reduce signs of aging while toning and tightening the skin. This advanced facial combines cutting-edge techniques with relaxation to leave your skin looking refreshed and radiant.

The Neveskin Facial Experience

Designed to enhance circulation and create a more lifted appearance, this facial includes:

  • Cold Therapy Toning: Using the Neveskin™ wand, cold temperatures are applied to the skin to help reduce puffiness, improve elasticity and temporarily increase circulation.
  • Lifting Technique: Apply targeted application of cold therapy to focus on areas such as the under-eye and jawline helps to lift and tone the skin.
  • Relaxing Massage: A cold therapy massage enhances circulation and promotes a natural glow.

For best results, a series of five or more sessions of the Neveskin Facial is recommended. Alternate this facial with the Marini Retinol Plus Facial every two weeks for the best deep wrinkle treatment. 

Other Non-Invasive Restore Therapies That May Support Deep Wrinkle Facial Treatments

While these therapies don’t directly treat the appearance of wrinkles, they can support the action of deep wrinkle treatments by improving overall skin health. Our licensed Estheticians can help you create a personalized Wellness Plan that combines recommended facials with complementary therapies for more effective results. You can consider:

Hydrafacial™

As the name suggests, Hydrafacial™ deeply hydrates skin, while masterfully extracting impurities that can clog pores and lead to breakouts. The primary ingredients include restorative antioxidant peptides that reduce oxidative stress—a key cause behind premature collagen and elastin degradation.5 

Clients can supercharge this service with additional boosters and add-ons like lymphatic drainage to target specific issues.

Infrared Sauna

Infrared Sauna helps you sweat more by gently raising your body temperature. Within 45 minutes, it can enhance circulation and reduce inflammation. Increased sweating also helps your body detoxify and get rid of free radicals, which are known to be a major culprit behind oxidative stress and premature skin aging.6

Red Light Therapy

According to the American Academy of Dermatology Association, Red Light Therapy can be an effective treatment against fine lines and wrinkles. It stimulates collagen production, reduces dark spots, reduces inflammation and firms up skin, along with a host of other whole-body benefits. They cite studies that show that patients find improvements in skin textures within a few weeks of consistent exposure to near-infrared red light. 

IV Drip Therapies for Skin Health

IV Drip Therapy is designed to deliver potent nutrients directly into the bloodstream for 100% bioavailability, with different formulations focusing on specific outcomes. 

The Amplified Beauty Drip from our IV Drip Menu is perfect for nourishing and unlocking radiant skin. It contains two of nature’s most powerful antioxidants in the form of Glutathione and Vitamin C, both of which are known for their anti-aging and skin brightening properties.7,8 The cherry on top is the inclusion of Proline, a key component of collagen, for a complete boost to skin health.9

NAD+ and Niagen (NR) Therapy

NAD+ is a molecule found in every cell of the body that performs a range of biological functions, including cellular repair and detoxification. It also supports fibroblasts in preserving the structural integrity of cells and promotes healthy function of collagen and elastin.8 

According to Dr. Rachele Pjodenic, Restore’s Chief Science Officer, NAD+ levels decline naturally by 68% between the ages of 30-50 years—profoundly impacting skin appearance. This makes it even more important to replenish these as the age progresses.

Niagen (NR) is a precursor of NAD+ that is more easily absorbed by the body.

Choose between NAD+ IV Therapy, NAD+ IM Shot Therapy, Niagen (NR) IV Therapy and Niagen (NR) IM Shot Therapy to see numerous benefits for skin and general health. 

Who Should Consider Non-Invasive Deep Wrinkle Treatments?

Anyone with visible deep wrinkles can benefit from the listed non-invasive treatments in this guide. They are particularly a good fit for you if you:

  • Prefer natural-looking results with no downtime.
  • Have sensitive skin that may not tolerate more invasive procedures.
  • Want to delay injectables, lasers or other clinical interventions.
  • Are looking for consistent ways to maintain long-term skin health.

Achieve Your Goals for Wrinkle Treatment

Achieving results for deep wrinkles requires a thorough approach. By alternating Marini Retinol Plus Facials with Neveskin Facials, you can address wrinkles from multiple angles ensuring comprehensive skin rejuvenation. However, the absolute best course of action is to get personalized recommendations from our licensed and trained experts.

Book a free consultation to receive customized recommendations for your goals. 

FAQs for Best Deep Wrinkle Treatment

1. What is the best non-invasive treatment for deep wrinkles?

There’s no single best treatment for deep wrinkles, but the most effective non-invasive treatments work on a cellular level, stimulating new collagen in the deeper layers of the skin. The ones included in this guide provide science-backed ways to do just that.

2. Can facials really help with deep wrinkles?

Yes, facials with anti-aging ingredients like retinol can reduce sagging, fine lines and wrinkles effectively. Our licensed Estheticians recommend pairing our Marini Retinol Plus Facial with Neveskin Facial to tackle skin aging from multiple angles.

3. How long does it take to see results?

It all depends on your current skin health. The skin's texture, firmness and fine lines usually improve within a few weeks or months of consistent treatment. Deep wrinkles may require ongoing sessions to achieve noticeable changes.

4. Are non-invasive treatments safe for sensitive skin?

Non-invasive therapies are gentler than other aesthetic procedures and better suited for sensitive skin. They reduce the risk of irritation or downtime, and can be tailored to individual needs for gradual but safe skin improvements.

Medical services are provided by an independently-owned physician practice. Some services may require medical clearance and a prescription. We reserve the right to refuse service to anyone. Services, therapies, nutrients and prices may vary per location. The content on our site, blog posts, educational materials, apps, promotional newsletters, and any other written content are not intended to replace an evaluation with a qualified healthcare professional and are not intended as medical advice.

Citations

  1. Shin J‑W et al. (2019). Molecular Mechanisms of Dermal Aging and Antiaging Approaches. International Journal of Molecular Sciences, 20(9): 2126.
  2. Quan, T. Human Skin Aging and the Anti‑Aging Properties of Retinol. Biomolecules. 2023; 13(11):1614.
  3. Brown A et al. (2023). Natural Retinol Analogs Potentiate the Effects of Retinal on Aged and Photodamaged Skin: Results from In Vitro to Clinical Studies. Dermatology and Therapy (Heidelb), 13(10):2299-2317.
  4. Boulares A et al. (2025). Cold and longevity: Can cold exposure counteract aging? Biogerontology. article PII S0024320525000645.
  5. Zhang Y et al. (2024). New insights into antioxidant peptides: An overview of efficient screening, evaluation models, molecular mechanisms, and applications. Antioxidants, 13(2): 203.
  6. Poljšak B et al. (2012). Free radicals and extrinsic skin aging. PMC3299230.
  7. Weschawalit S et al. (2017). Glutathione and its anti‑aging and antimelanogenic effects. Clin Cosmet Investig Dermatol, 10:147–153.
  8. De Dormael R et al. (2019). Vitamin C prevents ultraviolet‑induced pigmentation in healthy volunteers: Bayesian meta‑analysis results from 31 randomized controlled versus vehicle clinical studies. Journal of Clinical and Aesthetic Dermatology, 12(2): E53–E59.
  9. Quan T et al. (2025). Molecular mechanism of melatonin‑mediated mitophagy regulating proline production to ameliorate skin aging. Experimental Gerontology, 204:112738.
  10. Conlon, N. J., et al. (2021). The role of NAD⁺ in regenerative medicine. Plastic and Reconstructive Surgery, 150(4 Suppl), 41S–48S.

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