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Vitamin D & Gut Health

Restore Hyper Wellness Writer
Written by:
Restore Hyper Wellness Writer
Dr. Rachele Pojednic
Reviewed by:
Dr. Rachele Pojednic
Chief Science Officer
5 minute read
August 20, 2025
Man gets Vitamin D IM Shot from Nurse at Restore Hyper Wellness
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Vitamin D is known for its role in bone health and healthy aging, but did you know that it also has a strong influence over your gut health?

In this article, our experts explore the science behind Vitamin D and how it helps strengthen digestion and restore balance to elevate your overall well-being.

Vitamin D & Gut Health 

Strengthens the Gut Barrier

Vitamin D plays a crucial role in maintaining a healthy gut barrier, which is the thin but powerful lining in the intestine that keeps toxins out while allowing nutrients in. Without enough Vitamin D, the gut lining can become weakened, reducing its ability to protect the body from harmful germs, pathogens and chronic inflammation. Adequate Vitamin D levels strengthen the gut barrier’s resilience, which supports immune cells in the gut and reduces inflammation.1

Balances Out the Digestive Bacteria

Probiotics and yogurt are often talked about in regard to healthy gut bacteria, but Vitamin D can also help keep digestive bacteria in balance.

By regulating immune responses and reducing inflammation, Vitamin D creates a condition where “good” bacteria can thrive while also helping to prevent the overgrowth of harmful bacteria. This more balanced microbiome can lead to better digestion and nutrient absorption, necessary for overall health and wellness.2 

Regulates the Immune System

Vitamin D supports the production and function of immune cells like T cells and macrophages, which detect and destroy viruses and bacteria. Since 70% of immune cells are located in the gut, Vitamin D has a direct impact on immune health. 

It also regulates excessive immune responses that can result in chronic inflammation and autoimmune issues. This balance ensures your immune system stays healthy but not overactive.2 

Helps Reduce Risk of Disorders & Diseases

By supporting a strong gut barrier, promoting a balanced microbiome and reducing inflammation in the digestive tract, Vitamin D has been found to help lower the risk of digestive disorders and diseases like inflammatory bowel disease, irritable bowel syndrome, celiac disease and certain infections.3 Higher levels of Vitamin D have also been shown to help lower the risk for diverticulitis and colon cancer.4

Need a Boost of Vitamin D? Try IM Shots

Intramuscular (IM) Shots deliver targeted injections directly into muscle tissue for approximately 70-90% bioavailability. While IV Drip Therapy takes 60-90 minutes, IM Shots take about 5 minutes and allow for quick and efficient absorption of nutrients into the bloodstream. After the injection, Vitamin D is carried to various tissues and organs throughout the body, where it can start to produce the intended effects.

Boost Your Gut Health with Vitamin D

By reinforcing the intestinal barrier, supporting a diverse microbiome and calming inflammation, Vitamin D can help maintain a balanced digestive and immune system. Ensure your body has adequate Vitamin D with IM Shots at your local Restore studio, and take a simple but powerful step toward long-term gut health and overall wellness. 

Protect your health from the inside out by booking your IM Shot appointment today!

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Citations

  1. Fakhoury H, Kvietys P, Anouti F. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. The Journal of Steroid Biochemistry and Molecular Biology. June 2020. https://www.sciencedirect.com/science/article/abs/pii/S0960076019306090?
  2. Wiertsema S, Bergenhenegouwen J, Garssen J. Knippels L. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. March 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8001875/
  3. Wang J, Mei L, Hao Y, Xu Y, Yang Q, Dai Z, Yang Y, Wu Z, Ji Y. Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal Diseases. Nutrients. July 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11279818/
  4. Johnson D. The Overlooked Link Between Vitamin D and GI Health. Medscape. May 2025. https://www.medscape.com/viewarticle/overlooked-link-between-vitamin-d-and-gi-health-2025a1000bki

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